Recently, topical hyaluronic acid has been appearing on pharmacy shelves and search engines. Simply put, our body naturally produces it to make our skin appear young, plump, and free of wrinkles. But what if this acid decreases as we age? Do we accept dry skin at that point or do we turn to the latest scientific developments? In fact, science has been able to manufacture hyaluronic acid in several forms to suit everyone.
In this article, we will learn about natural and manufactured hyaluronic acid and its effect on skin moisture and improving the appearance of wrinkles.
Hyaluronic Acid: Definition and Function
It is one of the effective antioxidants produced by our bodies naturally through an enzyme called hyaluronic acid synthase. This enzyme facilitates the joining of two types of sugars, D-glucuronic acid and N-acetyl glucosamine, which are then converted into hyaluronic acid.
The main function of hyaluronic acid related to the skin is to bind to water molecules within the skin to maintain tissue moisture and hydration. It retains moisture for as long as possible, just like a sponge. It is naturally found in many areas of the human body, including the skin, where it is considered one of the essential components that maintain skin moisture. As we age, the natural production of hyaluronic acid slows down, causing our skin to become drier and duller, and the lack of hydration can lead to loss of elasticity, making us look for external sources that perform its function. Additionally, exposure to external factors such as UV rays from the sun, tobacco smoke, and pollution can reduce its amounts in the skin.
Synthetic Hyaluronic Acid
Hyaluronic acid used in cosmetic and skin care products is primarily manufactured in the lab using the Streptococcus bacteria strain and other chemicals as raw materials. This manufacturing process is called bio-synthesis.
You can obtain it through a variety of products, from serums and creamy moisturizers to sheet masks, night creams, lip products, and injectable gels. Hyaluronic acid is considered natural if it is extracted from an animal source without any additional molecule synthesis. It can be naturally obtained from the combs of roosters or from the aqueous mixture of bovine eyes.
Studies Show the Effectiveness of Hyaluronic Acid.
Due to its ability to hold 1000 times its weight in moisture inside the skin for a long period, it has a significant effect on moisturizing and softening the skin, as well as reducing the appearance of wrinkles.
A recent clinical trial that lasted 6 weeks investigated the effects of topical hyaluronic acid use and found a clinical improvement in skin hydration, fine lines, and wrinkles. After 6 weeks of use, fine lines decreased by 31% and wrinkles decreased by 14%. Therefore, it seems to work well in reducing wrinkles after 6 weeks.
In 2014, a study was conducted on 33 women with an average age of 45.2 for eight weeks to measure the anti-wrinkle effectiveness of nano hyaluronic acid. The study results showed a statistically significant moisturizing effect for the product group (cleanser, serum, cream, after 2, 4, and 8 weeks of treatment), and skin roughness measurements showed a significantly smoother skin structure after two weeks of treatment.
The treatment showed a significant improvement in skin elasticity after two and eight weeks of treatment: hyaluronic acid showed a significant benefit in reducing the depth of wrinkles (up to 40%), moisturizing the skin (up to 96%), and tightening and improving skin elasticity (up to 55%) at the end of eight weeks.
The effect of hyaluronic acid on wrinkles around the eye after using it for only 57 days


Why is Topical Hyaluronic Acid Considered the Optimal Choice for Moisturized Skin?
- It retains moisture: it helps renew and maintain cell moisture, resulting in hydrated and plump skin.
- It reduces the appearance of wrinkles: as dry skin is one of the main causes of wrinkles, hyaluronic acid compensates for lost moisture and helps reduce the appearance of fine lines.
- Fast absorption: unlike some skincare products, hyaluronic acid quickly absorbs into the skin, meaning you use less of the product.
- Safe for skin: it does not cause irritation when used in balanced concentrations (1% – 2%) and is suitable for all skin types.
- Available without prescription: unlike some high-end skincare ingredients, hyaluronic acid products are available in most beauty stores and pharmacies.
- Can be used as a primer alternative before applying makeup
Why was your Experience Bad with Topical Hyaluronic Acid?
The concentration of hyaluronic acid in the product: you may have used a product with a low concentration of hyaluronic acid (less than 1%), which is not effective enough to achieve the marketed results. Or you may have used a product with a very high percentage of hyaluronic acid (much higher than 2%). Since hyaluronic acid attracts all of these water molecules, if the concentration is too high, it can actually take water from your skin, negatively affecting its primary purpose of retaining moisture.
If used on dry skin, it can have a negative impact and increase dryness. It is recommended to apply hyaluronic acid on moist skin – after moisturizing – to maintain this moisture.
Hyaluronic Acid Serum from Dermaliscio
For these reasons, Dermaliscio Hyaluronic Acid Serum stands out
A 2014 study published in the Journal of Clinical and Aesthetic Dermatology demonstrates the effectiveness of nano-hyaluronic acid in maintaining skin elasticity and hydration levels. It was found that the effectiveness of Nano Hyaluronic Acid increases skin hydration levels by 96% and increases skin firmness and elasticity by 55%.
It’s perfect for you because the active concentration of pure double molecular weight in Hyaluronic Acid Serum 8000, promotes skin cell renewal while remaining a less expensive alternative to fillers (fillers and Botox).
Promotes cell regeneration, fills wrinkles, gently lifts lines, reduces enlarged pores, increases skin elasticity around the eyes, and skin glow. Its delicate texture makes it ideal for all skin types and all ages.
It is recommended to apply it directly to damp skin. Dear, you can use it as a primer before applying makeup. For perfect hydration and an extra layer of protection.
Composition and Ingredients
- Hyaluronic acid: 10-50 kDa
- Low molecular weight hyaluronic acid is able to penetrate the skin. Moisturizes the skin, increases skin elasticity, and regenerates cells.
- Hyaluronic Oligo: 5000 kDa
- Hyaluronic oligomer has a molecular size of about 1 nm. It can penetrate the skin to reach the deepest layers, moisturizing the skin from the inside and the outside. Its moisture lasts up to 3 days because oligo hyaluronic acid has a high water-holding capacity
- peptides: Small proteins that result from the breakdown of collagen and are important as an active gel-reconstructing component.
Customers Feedback

It’s the right time to add it to your current routine because your skin deserves to stay hydrated and radiant. You can add a comment below if you have any questions or opinions you would like to share.
Resources: Health Line, NCBI, Sciencing, Health Harvard
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